| 13. Jornada | 20.11.2021 | Sparta Rotterdam | - | FC Twente | 0:1 | ||||
| 14. Jornada | 28.11.2021 | FC Twente | - | Feyenoord | 0:0 | ||||
| 15. Jornada | 05.12.2021 | Go Ahead Eagles | - | FC Twente | 1:2 | ||||
| 16. Jornada | 12.12.2021 | FC Twente | - | RKC Waalwijk | 2:1 | ||||
| 17. Jornada | 18.12.2021 | PEC Zwolle | - | FC Twente | 1:3 | ||||
| 20. Jornada | 22.01.2022 | Willem II | - | FC Twente | 0:1 | ||||
| 21. Jornada | 05.02.2022 | FC Twente | - | Vitesse | 3:0 | ||||
| 22. Jornada | 13.02.2022 | AFC Ajax | - | FC Twente | 5:0 | ||||
| 23. Jornada | 20.02.2022 | FC Twente | - | Go Ahead Eagles | 2:2 | ||||
| 24. Jornada | 25.02.2022 | RKC Waalwijk | - | FC Twente | 1:2 | ||||
| 26. Jornada | 13.03.2022 | AZ Alkmaar | - | FC Twente | 0:1 | ||||
| 27. Jornada | 19.03.2022 | FC Twente | - | PEC Zwolle | 1:0 | ||||
| 28. Jornada | 02.04.2022 | FC Twente | - | PSV | 3:3 | ||||
| 30. Jornada | 22.04.2022 | FC Twente | - | Sparta Rotterdam | 2:0 | ||||
| 31. Jornada | 30.04.2022 | Heracles Almelo | - | FC Twente | 1:1 | ||||
| 32. Jornada | 07.05.2022 | FC Twente | - | Fortuna Sittard | 1:2 |  |
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| 33. Jornada | 11.05.2022 | FC Twente | - | FC Groningen | 3:0 |  |
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| 34. Jornada | 15.05.2022 | Feyenoord | - | FC Twente | 1:2 |
República Checa