| 6. Jornada | 21.08.2021 | FK Kaluga | - | FK Sakhalin | 1:1 |  |
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| 7. Jornada | 29.08.2021 | Arsenal Tula 2 | - | FK Kaluga | 1:0 | ||||
| 8. Jornada | 04.09.2021 | FK Kaluga | - | FK Ryazan | 0:2 | ||||
| 9. Jornada | 10.09.2021 | Sokol Saratov | - | FK Kaluga | 1:0 | ||||
| 10. Jornada | 14.09.2021 | FK Kaluga | - | Fakel Voronezh 2 | 2:1 | |
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| 11. Jornada | 18.09.2021 | Zenit Penza | - | FK Kaluga | 1:0 | ||||
| 12. Jornada | 26.09.2021 | FK Kaluga | - | Zenit Penza | 1:1 | ||||
| 13. Jornada | 30.09.2021 | FK Kaluga | - | Avangard Kursk | 2:1 | ||||
| 14. Jornada | 04.10.2021 | Dinamo Bryansk | - | FK Kaluga | 2:0 | ||||
| 15. Jornada | 10.10.2021 | FK Kaluga | - | Salyut Belgorod | 2:3 | ||||
| 19. Jornada | 31.10.2021 | FK Kaluga | - | Arsenal Tula 2 | 1:1 | ||||
| 21. Jornada | 10.11.2021 | FK Kaluga | - | Sokol Saratov | 0:1 |
Rusia