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| 15.08.2022 | 15:00 | Lanús II | - | Newell's Old Boys II | 2:0 (1:0) | |
| 15:00 | Huracán II | - | Independiente II | 2:2 (1:0) | ||
| 16:00 | Colón de Santa Fe II | - | Central Córdoba SdE II | 5:3 (4:2) | ||
| 16:00 | Godoy Cruz II | - | Sarmiento de Junín II | 0:2 (0:0) | ||
| 16.08.2022 | 15:00 | River Plate II | - | Arsenal de Sarandí II | 0:0 (0:0) | |
| 16:00 | Rosario Central II | - | Boca Juniors II | 0:6 (0:4) | ||
| 16:00 | Defensa y Justicia II | - | Barracas Central II | 3:1 (0:1) | ||
| 16:00 | Vélez Sarsfield II | - | Aldosivi II | 2:1 (2:0) | ||
| 17.08.2022 | 15:00 | Platense II | - | San Lorenzo II | 0:0 (0:0) | |
| 16:00 | Patronato de Paraná II | - | Talleres de Córdoba II | 0:1 (0:1) | ||
| 16:00 | Atlético Tucumán II | - | Tigre II | 2:0 (0:0) | ||
| 16:00 | Gimnasia de La Plata II | - | Unión de Santa Fe II | 1:1 (0:1) | ||
| 18.08.2022 | 15:00 | Racing Club II | - | Banfield II | 0:0 (0:0) | |
| 16:00 | Estudiantes II | - | Argentinos Juniors II | 1:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Boca Juniors II | 14 | 9 | 1 | 4 | 26:10 | 16 | 28 |
| 2 |
|
River Plate II | 14 | 9 | 1 | 4 | 19:10 | 9 | 28 |
| 3 |
|
Vélez Sarsfield II | 14 | 8 | 2 | 4 | 27:10 | 17 | 26 |
| 4 |
|
Newell's Old Boys II | 14 | 7 | 5 | 2 | 19:11 | 8 | 26 |
| 5 |
|
Defensa y Justicia II | 14 | 8 | 2 | 4 | 18:15 | 3 | 26 |
| 6 |
|
Rosario Central II | 14 | 7 | 3 | 4 | 27:21 | 6 | 24 |
| 7 |
|
Huracán II | 14 | 7 | 3 | 4 | 26:23 | 3 | 24 |
| 8 |
|
Argentinos Juniors II | 14 | 6 | 5 | 3 | 22:15 | 7 | 23 |
| 9 |
|
Gimnasia de La Plata II | 14 | 6 | 4 | 4 | 21:16 | 5 | 22 |
| 10 |
|
Atlético Tucumán II | 14 | 6 | 3 | 5 | 22:19 | 3 | 21 |
| 11 |
|
Tigre II | 14 | 6 | 3 | 5 | 15:17 | -2 | 21 |
| 12 |
|
Colón de Santa Fe II | 14 | 5 | 5 | 4 | 16:21 | -5 | 20 |
| 13 |
|
Independiente II | 14 | 5 | 4 | 5 | 22:19 | 3 | 19 |
| 14 |
|
Lanús II | 14 | 6 | 1 | 7 | 24:27 | -3 | 19 |
| 15 |
|
Racing Club II | 14 | 4 | 6 | 4 | 22:15 | 7 | 18 |
| 16 |
|
Arsenal de Sarandí II | 14 | 4 | 6 | 4 | 13:10 | 3 | 18 |
| 17 |
|
Unión de Santa Fe II | 14 | 4 | 6 | 4 | 13:13 | 0 | 18 |
| 18 |
|
Central Córdoba SdE II | 14 | 5 | 3 | 6 | 15:20 | -5 | 18 |
| 19 |
|
Banfield II | 14 | 4 | 4 | 6 | 10:13 | -3 | 16 |
| 20 |
|
Aldosivi II | 14 | 5 | 1 | 8 | 24:33 | -9 | 16 |
| 21 |
|
San Lorenzo II | 14 | 4 | 3 | 7 | 17:20 | -3 | 15 |
| 22 |
|
Talleres de Córdoba II | 14 | 4 | 3 | 7 | 15:20 | -5 | 15 |
| 23 |
|
Estudiantes II | 14 | 3 | 6 | 5 | 11:16 | -5 | 15 |
| 24 |
|
Sarmiento de Junín II | 14 | 4 | 2 | 8 | 13:23 | -10 | 14 |
| 25 |
|
Patronato de Paraná II | 14 | 4 | 2 | 8 | 12:23 | -11 | 14 |
| 26 |
|
Platense II | 14 | 2 | 7 | 5 | 10:14 | -4 | 13 |
| 27 |
|
Godoy Cruz II | 14 | 3 | 4 | 7 | 14:22 | -8 | 13 |
| 28 |
|
Barracas Central II | 14 | 3 | 1 | 10 | 7:24 | -17 | 10 |
