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| 18.09.2021 | 21:00 | Gimnasia y Esgrima (CdU) | - | Belgrano de San Francisco | 1:2 (1:1) | |
| 23:00 | Chaco For Ever | - | Defensores Belgrano (VR) | 0:0 (0:0) | ||
| 19.09.2021 | 20:00 | Racing de Córdoba | - | Defensores de Pronunciamiento | 3:2 (1:1) | |
| 20:00 | Douglas Haig | - | Sarmiento de Resistencia | 2:1 (2:1) | ||
| 20:00 | Sportivo Las Parejas | - | Gimnasia y Tiro de Salta | 1:1 (0:1) | ||
| 20:30 | Central Norte | - | Unión de Sunchales | 3:2 (1:1) | ||
| 21:00 | Boca Unidos | - | Juventud Unida de Gualeguaychú | 3:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 22 | 13 | 7 | 2 | 33:11 | 22 | 46 |
| 2 |
|
Gimnasia y Tiro de Salta | 22 | 13 | 7 | 2 | 30:15 | 15 | 46 |
| 3 |
|
Central Norte | 22 | 9 | 10 | 3 | 32:21 | 11 | 37 |
| 4 |
|
Chaco For Ever | 22 | 9 | 9 | 4 | 28:17 | 11 | 36 |
| 5 |
|
Boca Unidos | 21 | 6 | 10 | 5 | 30:27 | 3 | 28 |
| 6 |
|
Juventud Unida de Gualeguaychú | 22 | 7 | 7 | 8 | 22:27 | -5 | 28 |
| 7 |
|
Sportivo Las Parejas | 21 | 6 | 8 | 7 | 21:21 | 0 | 26 |
| 8 |
|
Unión de Sunchales | 21 | 6 | 8 | 7 | 22:24 | -2 | 26 |
| 9 |
|
Defensores Belgrano (VR) | 21 | 7 | 5 | 9 | 25:29 | -4 | 26 |
| 10 |
|
Sarmiento de Resistencia | 22 | 6 | 7 | 9 | 28:32 | -4 | 25 |
| 11 |
|
Defensores de Pronunciamiento | 21 | 5 | 8 | 8 | 22:27 | -5 | 23 |
| 12 |
|
Belgrano de San Francisco | 22 | 4 | 10 | 8 | 22:30 | -8 | 22 |
| 13 |
|
Gimnasia y Esgrima (CdU) | 21 | 6 | 4 | 11 | 17:28 | -11 | 22 |
| 14 |
|
Douglas Haig | 21 | 5 | 4 | 12 | 12:19 | -7 | 19 |
| 15 |
|
Crucero del Norte | 21 | 4 | 6 | 11 | 15:31 | -16 | 18 |
| Playoff | |
| Próxima ronda |
