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| I | FC Metz | - | Montpellier | 2:1 | ||
| V | Montpellier | - | FC Metz | 1:0 | ||
| I: 02.04.1981 | V: 11.04.1981 | Campeones: Montpellier | ||||
| I | Bastia | - | Mónaco | 2:0 | ||
| V | Mónaco | - | Bastia | 2:1 | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: Bastia | ||||
| I | Nantes | - | Girondins de Burdeos | 1:4 | ||
| V | Girondins de Burdeos | - | Nantes | 6:4 | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: Girondins de Burdeos | ||||
| I | Havre AC | - | RC Lens | 1:0 | ||
| V | RC Lens | - | Havre AC | 2:0 pró. | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: RC Lens | ||||
| I | LB Châteauroux | - | Lille | 1:0 | ||
| V | Lille | - | LB Châteauroux | 2:0 | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: Lille | ||||
| I | La Sportive Thionvilloise | - | FC Martigues | 2:2 | ||
| V | FC Martigues | - | La Sportive Thionvilloise | 3:0 | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: FC Martigues | ||||
| I | AS Nancy Lorraine | - | Saint-Étienne | 2:1 | ||
| V | Saint-Étienne | - | AS Nancy Lorraine | 3:1 | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: Saint-Étienne | ||||
| I | RC Strasbourg | - | AS Angoulême | 2:0 | ||
| V | AS Angoulême | - | RC Strasbourg | 2:1 | ||
| I: 03.04.1981 | V: 11.04.1981 | Campeones: RC Strasbourg | ||||
