 |
 |
|
|
| 16.04.2022 | 00:00 | Atlético San Luis | - | Club León | 4:0 (2:0) | |
| 19:00 | Cruz Azul | - | CF Monterrey | 1:3 (1:1) | ||
| 17.04.2022 | 19:00 | Puebla FC | - | Club Necaxa | 0:1 (0:1) | |
| 18.04.2022 | 01:00 | FC Juárez | - | Gallos Blancos | 2:1 (0:0) | |
| 19.04.2022 | 00:00 | Deportivo Guadalajara | - | Pumas UNAM | 2:1 (0:1) | |
| 00:00 | Deportivo Toluca | - | Mazatlán FC | 2:0 (1:0) | ||
| 02:00 | CF Pachuca | - | Atlas Guadalajara | 2:2 (2:2) | ||
| 02:00 | UANL Tigres | - | Santos Laguna | 4:1 (1:1) | ||
| 04:00 | Club Tijuana | - | CF América | 2:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 15 | 14 | 0 | 1 | 51:12 | 39 | 42 |
| 2 |
|
UANL Tigres | 15 | 11 | 4 | 0 | 42:10 | 32 | 37 |
| 3 |
|
Deportivo Guadalajara | 15 | 11 | 4 | 0 | 25:6 | 19 | 37 |
| 4 |
|
CF América | 15 | 10 | 3 | 2 | 36:13 | 23 | 33 |
| 5 |
|
CF Pachuca | 15 | 9 | 2 | 4 | 27:17 | 10 | 29 |
| 6 |
|
Atlas Guadalajara | 15 | 6 | 6 | 3 | 25:23 | 2 | 24 |
| 7 |
|
Deportivo Toluca | 15 | 5 | 4 | 6 | 25:27 | -2 | 19 |
| 8 |
|
Club Tijuana | 15 | 3 | 9 | 3 | 20:25 | -5 | 18 |
| 9 |
|
Atlético San Luis | 15 | 4 | 5 | 6 | 19:26 | -7 | 17 |
| 10 |
|
Pumas UNAM | 15 | 4 | 4 | 7 | 13:14 | -1 | 16 |
| 11 |
|
Cruz Azul | 15 | 4 | 3 | 8 | 17:28 | -11 | 15 |
| 12 |
|
Gallos Blancos | 15 | 4 | 3 | 8 | 14:26 | -12 | 15 |
| 13 |
|
Club Necaxa | 15 | 3 | 5 | 7 | 15:28 | -13 | 14 |
| 14 |
|
Puebla FC | 15 | 3 | 3 | 9 | 10:21 | -11 | 12 |
| 15 |
|
Club León | 15 | 3 | 3 | 9 | 15:36 | -21 | 12 |
| 16 |
|
FC Juárez | 15 | 3 | 2 | 10 | 15:23 | -8 | 11 |
| 17 |
|
Santos Laguna | 15 | 3 | 2 | 10 | 13:28 | -15 | 11 |
| 18 |
|
Mazatlán FC | 15 | 2 | 4 | 9 | 9:28 | -19 | 10 |
| Playoff |
