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| 24.07.2010 | 16:45 | Spartak Vladikavkaz | - | FK Tom Tomsk | 2:1 (0:1) | |
| 18:30 | FK Rostov | - | Zenit | 1:3 (0:1) | ||
| 19:00 | Rubin Kazan | - | Dinamo Moskva | 2:0 (0:0) | ||
| 25.07.2010 | 12:15 | Sibir Novosibirsk | - | Lokomotiv Moskva | 2:2 (0:2) | |
| 14:30 | FK Amkar Perm | - | FK Saturn | 0:1 (0:1) | ||
| 16:45 | Anzhi Makhachkala | - | Terek Grozny | 1:0 (0:0) | ||
| 18:30 | Krylia Sovetov | - | Spartak Moskva | 0:0 (0:0) | ||
| 19:00 | CSKA Moscú | - | Spartak Nalchik | 1:2 (1:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 14 | 11 | 3 | 0 | 23:6 | 17 | 36 |
| 2 |
|
Rubin Kazan | 14 | 8 | 5 | 1 | 15:3 | 12 | 29 |
| 3 |
|
CSKA Moscú | 14 | 8 | 3 | 3 | 22:12 | 10 | 27 |
| 4 |
|
Spartak Nalchik | 14 | 7 | 4 | 3 | 19:14 | 5 | 25 |
| 5 |
|
Lokomotiv Moskva | 14 | 6 | 4 | 4 | 20:14 | 6 | 22 |
| 6 |
|
Spartak Moskva | 14 | 5 | 5 | 4 | 19:16 | 3 | 20 |
| 7 |
|
FK Rostov | 14 | 6 | 1 | 7 | 15:22 | -7 | 19 |
| 8 |
|
Dinamo Moskva | 14 | 4 | 6 | 4 | 15:15 | 0 | 18 |
| 9 |
|
FK Tom Tomsk | 14 | 5 | 3 | 6 | 17:20 | -3 | 18 |
| 10 |
|
Terek Grozny | 14 | 4 | 5 | 5 | 13:13 | 0 | 17 |
| 11 |
|
Anzhi Makhachkala | 14 | 4 | 4 | 6 | 16:16 | 0 | 16 |
| 12 |
|
Spartak Vladikavkaz | 14 | 4 | 3 | 7 | 15:22 | -7 | 15 |
| 13 |
|
FK Saturn | 14 | 3 | 5 | 6 | 10:13 | -3 | 14 |
| 14 |
|
FK Amkar Perm | 14 | 3 | 3 | 8 | 9:16 | -7 | 12 |
| 15 |
|
Sibir Novosibirsk | 14 | 2 | 3 | 9 | 19:31 | -12 | 9 |
| 16 |
|
Krylia Sovetov | 14 | 2 | 3 | 9 | 8:22 | -14 | 9 |
| Champions League | |
| CL Ronda previa | |
| Europa League | |
| Descenso |
