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| 20.11.2010 | 12:00 | CSKA Moscú | - | Spartak Moskva | 3:1 (0:1) | |
| 12:00 | Anzhi Makhachkala | - | FK Saturn | 1:2 (0:0) | ||
| 12:00 | Spartak Vladikavkaz | - | Terek Grozny | 2:1 (0:1) | ||
| 12:00 | FK Amkar Perm | - | Spartak Nalchik | 3:1 (1:1) | ||
| 12:00 | FK Rostov | - | Lokomotiv Moskva | 1:2 (0:0) | ||
| 12:00 | Krylia Sovetov | - | Dinamo Moskva | 1:0 (0:0) | ||
| 12:00 | Rubin Kazan | - | Zenit | 2:2 (0:1) | ||
| 12:00 | Sibir Novosibirsk | - | FK Tom Tomsk | 0:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 29 | 20 | 7 | 2 | 61:21 | 40 | 67 |
| 2 |
|
CSKA Moscú | 29 | 18 | 7 | 4 | 51:22 | 29 | 61 |
| 3 |
|
Rubin Kazan | 29 | 15 | 12 | 2 | 37:16 | 21 | 57 |
| 4 |
|
Spartak Moskva | 29 | 13 | 9 | 7 | 42:32 | 10 | 48 |
| 5 |
|
Lokomotiv Moskva | 29 | 13 | 8 | 8 | 34:29 | 5 | 47 |
| 6 |
|
Spartak Nalchik | 29 | 12 | 8 | 9 | 39:34 | 5 | 44 |
| 7 |
|
Dinamo Moskva | 29 | 9 | 12 | 8 | 37:30 | 7 | 39 |
| 8 |
|
FK Tom Tomsk | 29 | 9 | 7 | 13 | 32:42 | -10 | 34 |
| 9 |
|
FK Rostov | 29 | 10 | 4 | 15 | 26:41 | -15 | 34 |
| 10 |
|
FK Saturn | 29 | 8 | 9 | 12 | 26:37 | -11 | 33 |
| 11 |
|
Terek Grozny | 29 | 8 | 8 | 13 | 27:33 | -6 | 32 |
| 12 |
|
Krylia Sovetov | 29 | 7 | 9 | 13 | 28:40 | -12 | 30 |
| 13 |
|
Anzhi Makhachkala | 29 | 8 | 6 | 15 | 26:38 | -12 | 30 |
| 14 |
|
FK Amkar Perm | 29 | 8 | 5 | 16 | 24:35 | -11 | 29 |
| 15 |
|
Spartak Vladikavkaz | 29 | 7 | 8 | 14 | 24:40 | -16 | 29 |
| 16 |
|
Sibir Novosibirsk | 29 | 4 | 7 | 18 | 33:57 | -24 | 19 |
| Champions League | |
| CL Ronda previa | |
| Europa League | |
| Descenso |
