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| 15.03.2022 | 10:00 | Krylia Sovetov | - | FK Rostov | 1:5 (1:3) | |
| 11:00 | Rubin Kazan | - | Lokomotiv Moskva | 2:0 (1:0) | ||
| 12:00 | CSKA Moskva | - | FK Chertanovo | 1:0 (1:0) | ||
| 13:00 | Dinamo Moskva | - | PFC Sochi | 0:1 (0:0) | ||
| 14:00 | Spartak Moskva | - | Zenit St. Petersburg | 0:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FK Rostov | 20 | 15 | 2 | 3 | 53:18 | 35 | 47 |
| 2 |
|
CSKA Moskva | 20 | 15 | 1 | 4 | 44:16 | 28 | 46 |
| 3 |
|
Dinamo Moskva | 20 | 13 | 1 | 6 | 43:29 | 14 | 40 |
| 4 |
|
Lokomotiv Moskva | 20 | 12 | 4 | 4 | 33:20 | 13 | 40 |
| 5 |
|
Krylia Sovetov | 20 | 11 | 3 | 6 | 27:28 | -1 | 36 |
| 6 |
|
Zenit St. Petersburg | 20 | 11 | 1 | 8 | 50:29 | 21 | 34 |
| 7 |
|
FK Chertanovo | 20 | 10 | 4 | 6 | 33:25 | 8 | 34 |
| 8 |
|
PFC Sochi | 20 | 11 | 1 | 8 | 34:31 | 3 | 34 |
| 9 |
|
Spartak Moskva | 20 | 10 | 3 | 7 | 33:22 | 11 | 33 |
| 10 |
|
Rubin Kazan | 20 | 8 | 6 | 6 | 41:32 | 9 | 30 |
