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| 04.03.2022 | 18:00 | Yeni Malatyaspor | - | Adana Demirspor | 1:0 (0:0) | |
| 05.03.2022 | 14:00 | Çaykur Rizespor | - | Giresunspor | 1:2 (1:1) | |
| 14:00 | Göztepe | - | Kasımpaşa SK | 2:3 (1:1) | ||
| 17:00 | Konyaspor | - | Galatasaray | 2:0 (2:0) | ||
| 06.03.2022 | 14:00 | Fatih Karagümrük SK | - | Altay Izmir | 0:0 (0:0) | |
| 17:00 | Antalyaspor | - | Sivasspor | 1:0 (1:0) | ||
| 17:00 | Fenerbahçe | - | Trabzonspor | 1:1 (0:1) | ||
| 07.03.2022 | 18:00 | Beşiktaş | - | İstanbul Başakşehir | 2:2 (1:2) | |
| 18:00 | Gaziantep FK | - | Hatayspor | 2:2 (1:2) | ||
| 18:00 | Kayserispor | - | Alanyaspor | 1:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 28 | 20 | 7 | 1 | 52:21 | 31 | 67 |
| 2 |
|
Konyaspor | 28 | 15 | 7 | 6 | 44:29 | 15 | 52 |
| 3 |
|
İstanbul Başakşehir | 28 | 14 | 5 | 9 | 41:28 | 13 | 47 |
| 4 |
|
Fenerbahçe | 28 | 13 | 8 | 7 | 43:32 | 11 | 47 |
| 5 |
|
Alanyaspor | 28 | 13 | 7 | 8 | 51:42 | 9 | 46 |
| 6 |
|
Adana Demirspor | 28 | 12 | 9 | 7 | 42:28 | 14 | 45 |
| 7 |
|
Beşiktaş | 28 | 12 | 9 | 7 | 42:36 | 6 | 45 |
| 8 |
|
Hatayspor | 28 | 13 | 4 | 11 | 44:45 | -1 | 43 |
| 9 |
|
Fatih Karagümrük SK | 28 | 11 | 7 | 10 | 33:40 | -7 | 40 |
| 10 |
|
Kayserispor | 28 | 10 | 8 | 10 | 41:42 | -1 | 38 |
| 11 |
|
Gaziantep FK | 28 | 10 | 7 | 11 | 36:39 | -3 | 37 |
| 12 |
|
Galatasaray | 28 | 9 | 8 | 11 | 37:41 | -4 | 35 |
| 13 |
|
Antalyaspor | 28 | 9 | 8 | 11 | 29:35 | -6 | 35 |
| 14 |
|
Sivasspor | 28 | 8 | 10 | 10 | 35:35 | 0 | 34 |
| 15 |
|
Kasımpaşa SK | 28 | 8 | 8 | 12 | 40:42 | -2 | 32 |
| 16 |
|
Giresunspor | 28 | 9 | 5 | 14 | 29:32 | -3 | 32 |
| 17 |
|
Göztepe | 28 | 7 | 6 | 15 | 34:44 | -10 | 27 |
| 18 |
|
Altay Izmir | 28 | 7 | 5 | 16 | 29:41 | -12 | 26 |
| 19 |
|
Çaykur Rizespor | 28 | 6 | 5 | 17 | 25:50 | -25 | 23 |
| 20 |
|
Yeni Malatyaspor | 28 | 5 | 5 | 18 | 23:48 | -25 | 20 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
