| 1. Jornada | 23.07.2021 | FC Juárez [Sub 18] | - | Deportivo Toluca [Sub 18] | 1:2 | ||||
| 2. Jornada | 01.08.2021 | Deportivo Toluca [Sub 18] | - | UANL Tigres [Sub 18] | 4:0 | ||||
| 3. Jornada | 06.08.2021 | Club Tijuana [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:0 | ||||
| 4. Jornada | 14.08.2021 | Cruz Azul [Sub 18] | - | Deportivo Toluca [Sub 18] | 0:0 | ||||
| 5. Jornada | 17.08.2021 | Deportivo Toluca [Sub 18] | - | Mazatlán FC [Sub 18] | 0:1 | ||||
| 6. Jornada | 21.08.2021 | Atlas Guadalajara [Sub 18] | - | Deportivo Toluca [Sub 18] | 2:0 | ||||
| 9. Jornada | 18.09.2021 | Deportivo Toluca [Sub 18] | - | CF América [Sub 18] | 0:1 | ||||
| 15. Jornada | 24.10.2021 | Santos Laguna [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:1 | ||||
| 17. Jornada | 05.11.2021 | Puebla FC [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:1 |
México