| 1. Jornada | 20.07.2021 | Godoy Cruz | - | Rosario Central | 2:1 | ||||
| 2. Jornada | 25.07.2021 | Rosario Central | - | Vélez Sarsfield | 1:0 | ||||
| 3. Jornada | 29.07.2021 | Gimnasia de La Plata | - | Rosario Central | 1:0 | ||||
| 4. Jornada | 03.08.2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 5. Jornada | 07.08.2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Jornada | 15.08.2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 7. Jornada | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 10. Jornada | 05.09.2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Jornada | 15.09.2021 | Banfield | - | Rosario Central | 1:2 |  |
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| 13. Jornada | 25.09.2021 | Talleres de Córdoba | - | Rosario Central | 4:1 |  |
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| 14. Jornada | 03.10.2021 | Rosario Central | - | Argentinos Juniors | 0:1 | ||||
| 15. Jornada | 09.10.2021 | Estudiantes | - | Rosario Central | 2:2 | ||||
| 16. Jornada | 15.10.2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Jornada | 05.12.2021 | CA Lanús | - | Rosario Central | 2:2 | ||||
| 25. Jornada | 11.12.2021 | Rosario Central | - | Huracán | 1:4 |
Argentina