| 2. Jornada | 01.08.2021 | Deportivo Toluca [Sub 20] | - | UANL Tigres [Sub 20] | 2:0 | ||||
| 3. Jornada | 07.08.2021 | Club Tijuana [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 |  |
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| 4. Jornada | 14.08.2021 | Cruz Azul [Sub 20] | - | Deportivo Toluca [Sub 20] | 2:2 | ||||
| 9. Jornada | 18.09.2021 | Deportivo Toluca [Sub 20] | - | CF América [Sub 20] | 3:1 |  |
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| 11. Jornada | 22.09.2021 | CF Monterrey [Sub 20] | - | Deportivo Toluca [Sub 20] | 1:0 | |
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| 13. Jornada | 17.10.2021 | Deportivo Guadalajara [Sub 20] | - | Deportivo Toluca [Sub 20] | 4:1 | |
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| 14. Jornada | 20.10.2021 | Deportivo Toluca [Sub 20] | - | Club Necaxa [Sub 20] | 0:1 |
México