| 1. Jornada | 08.01.2022 | CF Pachuca [Sub 16] | - | Puebla FC [Sub 16] | 2:2 | ||||
| 2. Jornada | 15.01.2022 | Puebla FC [Sub 16] | - | Gallos Blancos [Sub 16] | 2:0 | ||||
| 8. Jornada | 26.02.2022 | Cruz Azul [Sub 16] | - | Puebla FC [Sub 16] | 1:2 | ||||
| 9. Jornada | 05.03.2022 | Puebla FC [Sub 16] | - | FC Juárez [Sub 16] | 6:0 | ||||
| 10. Jornada | 12.03.2022 | Deportivo Toluca [Sub 16] | - | Puebla FC [Sub 16] | 3:4 | ||||
| 12. Jornada | 26.03.2022 | Puebla FC [Sub 16] | - | Club Necaxa [Sub 16] | 2:3 | ||||
| 13. Jornada | 02.04.2022 | Gallos Blancos [Sub 16] | - | Puebla FC [Sub 16] | 2:1 | ||||
| 15. Jornada | 16.04.2022 | FC Juárez [Sub 16] | - | Puebla FC [Sub 16] | 0:1 | ||||
| 16. Jornada | 23.04.2022 | Puebla FC [Sub 16] | - | Cruz Azul [Sub 16] | 2:3 |
México