| 10. Jornada | 10.10.2021 | Herrera FC | - | Plaza Amador | 0:2 | ||||
| 11. Jornada | 18.10.2021 | Herrera FC | - | Alianza | 1:1 | ||||
| 12. Jornada | 24.10.2021 | Herrera FC | - | Independiente de La Chorrera | 2:1 | ||||
| 13. Jornada | 31.10.2021 | Atlético Chiriquí | - | Herrera FC | 0:0 | ||||
| 14. Jornada | 07.11.2021 | Herrera FC | - | Veraguas Club Deportivo | 1:1 | ||||
| 15. Jornada | 13.11.2021 | Herrera FC | - | San Francisco FC | 2:1 |  |
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| 16. Jornada | 20.11.2021 | UD Universitario | - | Herrera FC | 1:2 |
Panamá