| 1. Jornada | 14.02.2021 | San Lorenzo | - | Arsenal de Sarandí | 2:1 | ||||
| 2. Jornada | 23.02.2021 | Colón de Santa Fe | - | San Lorenzo | 2:0 | ||||
| 3. Jornada | 28.02.2021 | San Lorenzo | - | Central Córdoba SdE | 0:4 | ||||
| 4. Jornada | 07.03.2021 | San Lorenzo | - | Huracán | 1:1 | ||||
| 5. Jornada | 15.03.2021 | Banfield | - | San Lorenzo | 0:0 | ||||
| 6. Jornada | 21.03.2021 | San Lorenzo | - | Aldosivi | 1:2 | ||||
| 7. Jornada | 30.03.2021 | Estudiantes | - | San Lorenzo | 0:2 | ||||
| 8. Jornada | 03.04.2021 | San Lorenzo | - | Rosario Central | 2:0 |  |
|||
| 9. Jornada | 10.04.2021 | Platense | - | San Lorenzo | 2:4 | ||||
| 10. Jornada | 17.04.2021 | San Lorenzo | - | Argentinos Juniors | 1:1 | |
|||
| 11. Jornada | 25.04.2021 | River Plate | - | San Lorenzo | 1:2 | ||||
| 12. Jornada | 02.05.2021 | San Lorenzo | - | Godoy Cruz | 1:0 |
Paraguay
