| 1. Jornada | 07.08.2021 | Guingamp (CFA) | - | FC Rouen 1899 | 0:0 | ||||
| 2. Jornada | 14.08.2021 | AS Vitré | - | Guingamp (CFA) | 0:4 | ||||
| 3. Jornada | 21.08.2021 | Guingamp (CFA) | - | FC Versailles | 0:3 | ||||
| 5. Jornada | 04.09.2021 | Guingamp (CFA) | - | Stade Plabennec | 2:1 | ||||
| 6. Jornada | 11.09.2021 | St-Pryvé St-Hilaire | - | Guingamp (CFA) | 1:1 | ||||
| 9. Jornada | 09.10.2021 | Guingamp (CFA) | - | Caen (CFA) | 1:1 | ||||
| 10. Jornada | 23.10.2021 | Guingamp (CFA) | - | AS Poissy | 1:1 |  |
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| 15. Jornada | 15.01.2022 | SO Romorantin | - | Guingamp (CFA) | 2:3 | |
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| 17. Jornada | 05.02.2022 | FC Versailles | - | Guingamp (CFA) | 1:1 | ||||
| 18. Jornada | 12.02.2022 | Guingamp (CFA) | - | US Saint-Malo | 0:0 | ||||
| 22. Jornada | 19.03.2022 | Guingamp (CFA) | - | Lorient (CFA) | 1:2 | ||||
| 23. Jornada | 26.03.2022 | Caen (CFA) | - | Guingamp (CFA) | 0:2 | ||||
| 28. Jornada | 14.05.2022 | US Granvillaise | - | Guingamp (CFA) | 3:4 | ||||
| 29. Jornada | 21.05.2022 | Guingamp (CFA) | - | SO Romorantin | 1:2 | ||||
| 30. Jornada | 28.05.2022 | FC Rouen 1899 | - | Guingamp (CFA) | 2:1 | |
Francia
Italia