| 1. Jornada | 09.01.2022 | Pumas UNAM [Sub 18] | - | Deportivo Toluca [Sub 18] | 1:0 | ||||
| 2. Jornada | 16.01.2022 | Deportivo Toluca [Sub 18] | - | Santos Laguna [Sub 18] | 2:2 |  |
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| 3. Jornada | 21.01.2022 | Mazatlán FC [Sub 18] | - | Deportivo Toluca [Sub 18] | 0:0 | ||||
| 4. Jornada | 06.02.2022 | Deportivo Toluca [Sub 18] | - | CF Monterrey [Sub 18] | 3:0 | ||||
| 5. Jornada | 12.02.2022 | Atlético San Luis [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:4 | |
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| 6. Jornada | 20.02.2022 | Deportivo Toluca [Sub 18] | - | Cruz Azul [Sub 18] | 1:1 | |
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| 7. Jornada | 24.02.2022 | Gallos Blancos [Sub 18] | - | Deportivo Toluca [Sub 18] | 0:2 | |
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| 8. Jornada | 01.03.2022 | Deportivo Toluca [Sub 18] | - | Club Tijuana [Sub 18] | 1:1 | ||||
| 9. Jornada | 04.03.2022 | Club Necaxa [Sub 18] | - | Deportivo Toluca [Sub 18] | 0:1 | ||||
| 10. Jornada | 13.03.2022 | Deportivo Toluca [Sub 18] | - | CF Pachuca [Sub 18] | 0:2 | ||||
| 11. Jornada | 20.03.2022 | CF América [Sub 18] | - | Deportivo Toluca [Sub 18] | 3:2 | ||||
| 12. Jornada | 03.04.2022 | Deportivo Toluca [Sub 18] | - | Puebla FC [Sub 18] | 0:1 | ||||
| 13. Jornada | 09.04.2022 | Deportivo Toluca [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 3:3 |
México