| 1. Jornada | 24.07.2021 | Caen | - | Rodez AF | 4:0 | ||||
| 3. Jornada | 07.08.2021 | Caen | - | FC Sochaux | 1:2 | ||||
| 5. Jornada | 21.08.2021 | Caen | - | AS Nancy Lorraine | 1:0 | ||||
| 4. Jornada | 25.08.2021 | AC Ajaccio | - | Caen | 2:0 | ||||
| 6. Jornada | 28.08.2021 | Nîmes Olympique | - | Caen | 0:0 | ||||
| 7. Jornada | 11.09.2021 | Caen | - | Pau FC | 1:2 | ||||
| 14. Jornada | 30.10.2021 | Caen | - | Grenoble Foot 38 | 0:1 | ||||
| 23. Jornada | 05.02.2022 | AS Nancy Lorraine | - | Caen | 1:1 | ||||
| 27. Jornada | 05.03.2022 | Dijon FCO | - | Caen | 1:0 | ||||
| 28. Jornada | 12.03.2022 | Caen | - | Toulouse | 4:1 | ||||
| 29. Jornada | 15.03.2022 | Valenciennes FC | - | Caen | 1:1 | ||||
| 30. Jornada | 19.03.2022 | Havre AC | - | Caen | 2:4 |  |
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| 32. Jornada | 09.04.2022 | Grenoble Foot 38 | - | Caen | 0:2 | |
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| 33. Jornada | 16.04.2022 | Caen | - | Amiens SC | 1:1 | ||||
| 34. Jornada | 19.04.2022 | Paris FC | - | Caen | 1:0 | ||||
| 35. Jornada | 23.04.2022 | Caen | - | AJ Auxerre | 1:1 | ||||
| 36. Jornada | 30.04.2022 | Guingamp | - | Caen | 2:1 | ||||
| 37. Jornada | 07.05.2022 | Caen | - | US Quevilly-Rouen | 2:0 | |
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| 38. Jornada | 14.05.2022 | Rodez AF | - | Caen | 2:0 |
Francia