| 1. Jornada | 08.08.2021 | Rennes | - | RC Lens | 1:1 | ||||
| 2. Jornada | 15.08.2021 | RC Lens | - | Saint-Étienne | 2:2 | ||||
| 4. Jornada | 29.08.2021 | RC Lens | - | Lorient | 2:2 | ||||
| 10. Jornada | 17.10.2021 | Montpellier | - | RC Lens | 1:0 |  |
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| 11. Jornada | 24.10.2021 | RC Lens | - | FC Metz | 4:1 | ||||
| 12. Jornada | 30.10.2021 | Lyon | - | RC Lens | 2:1 | ||||
| 14. Jornada | 21.11.2021 | Stade Brestois 29 | - | RC Lens | 4:0 | ||||
| 15. Jornada | 26.11.2021 | RC Lens | - | Angers | 2:2 | ||||
| 16. Jornada | 01.12.2021 | Clermont Foot 63 | - | RC Lens | 2:2 | |
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| 18. Jornada | 10.12.2021 | Nantes | - | RC Lens | 3:2 | ||||
| 19. Jornada | 22.12.2021 | Niza | - | RC Lens | 2:1 | ||||
| 20. Jornada | 08.01.2022 | RC Lens | - | Rennes | 1:0 | ||||
| 21. Jornada | 15.01.2022 | Saint-Étienne | - | RC Lens | 1:2 | ||||
| 22. Jornada | 22.01.2022 | RC Lens | - | Marsella | 0:2 | ||||
| 34. Jornada | 23.04.2022 | París Saint-Germain | - | RC Lens | 1:1 |  |
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| 36. Jornada | 08.05.2022 | Stade de Reims | - | RC Lens | 1:2 | ||||
| 38. Jornada | 21.05.2022 | RC Lens | - | Mónaco | 2:2 |
Francia