| 2. Jornada | 16.01.2022 | CF Pachuca [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 4:2 |  |
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| 3. Jornada | 22.01.2022 | Club León [Sub 18] | - | CF Pachuca [Sub 18] | 4:2 | ||||
| 6. Jornada | 20.02.2022 | CF América [Sub 18] | - | CF Pachuca [Sub 18] | 3:0 | ||||
| 7. Jornada | 24.02.2022 | CF Pachuca [Sub 18] | - | Mazatlán FC [Sub 18] | 3:1 | ||||
| 8. Jornada | 02.03.2022 | Atlas Guadalajara [Sub 18] | - | CF Pachuca [Sub 18] | 2:1 | ||||
| 10. Jornada | 13.03.2022 | Deportivo Toluca [Sub 18] | - | CF Pachuca [Sub 18] | 0:2 | ||||
| 11. Jornada | 19.03.2022 | CF Pachuca [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | ||||
| 12. Jornada | 03.04.2022 | Santos Laguna [Sub 18] | - | CF Pachuca [Sub 18] | 3:1 | ||||
| 13. Jornada | 11.04.2022 | CF Pachuca [Sub 18] | - | Club Tijuana [Sub 18] | 1:2 | ||||
| 14. Jornada | 15.04.2022 | FC Juárez [Sub 18] | - | CF Pachuca [Sub 18] | 2:0 | ||||
| 15. Jornada | 19.04.2022 | CF Pachuca [Sub 18] | - | Puebla FC [Sub 18] | 3:0 |
México