| 1. Jornada | 24.07.2021 | Deportivo Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 1:5 |  |
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| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 | ||||
| 4. Jornada | 12.08.2021 | Atlético San Luis [Sub 20] | - | Club Necaxa [Sub 20] | 1:2 | ||||
| 6. Jornada | 21.08.2021 | Atlético San Luis [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 7. Jornada | 27.08.2021 | Mazatlán FC [Sub 20] | - | Atlético San Luis [Sub 20] | 3:1 | ||||
| 8. Jornada | 10.09.2021 | Puebla FC [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | |
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| 9. Jornada | 16.09.2021 | Atlético San Luis [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 | ||||
| 14. Jornada | 21.09.2021 | FC Juárez [Sub 20] | - | Atlético San Luis [Sub 20] | 1:2 |  |
México
Estados Unidos