| 4. Jornada | 13.08.2021 | FC Juárez [Sub 20] | - | Club Tijuana [Sub 20] | 1:3 | ||||
| 9. Jornada | 16.09.2021 | Atlético San Luis [Sub 20] | - | Club Tijuana [Sub 20] | 3:0 | ||||
| 10. Jornada | 25.09.2021 | Club Tijuana [Sub 20] | - | Mazatlán FC [Sub 20] | 3:5 |  |
 |
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| 11. Jornada | 28.09.2021 | Club Necaxa [Sub 20] | - | Club Tijuana [Sub 20] | 2:2 | ||||
| 14. Jornada | 21.10.2021 | Club Tijuana [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 16. Jornada | 28.10.2021 | Atlas Guadalajara [Sub 20] | - | Club Tijuana [Sub 20] | 1:1 | |
México