| 1. Jornada | 20.07.2021 | Godoy Cruz | - | Rosario Central | 2:1 | ||||
| 2. Jornada | 25.07.2021 | Rosario Central | - | Vélez Sarsfield | 1:0 |  |
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| 3. Jornada | 29.07.2021 | Gimnasia de La Plata | - | Rosario Central | 1:0 | ||||
| 4. Jornada | 03.08.2021 | Rosario Central | - | Aldosivi | 1:2 |  |
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| 7. Jornada | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | |
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| 10. Jornada | 05.09.2021 | Rosario Central | - | Boca Juniors | 1:2 | ||||
| 11. Jornada | 15.09.2021 | Banfield | - | Rosario Central | 1:2 |  |
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| 16. Jornada | 15.10.2021 | Rosario Central | - | Patronato de Paraná | 3:2 | |
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| 17. Jornada | 19.10.2021 | Platense | - | Rosario Central | 1:1 | ||||
| 18. Jornada | 24.10.2021 | Rosario Central | - | Racing Club | 2:1 | ||||
| 21. Jornada | 20.11.2021 | Rosario Central | - | Atlético Tucumán | 3:1 | |
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| 22. Jornada | 25.11.2021 | Colón de Santa Fe | - | Rosario Central | 1:4 | |
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| 23. Jornada | 28.11.2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Jornada | 05.12.2021 | CA Lanús | - | Rosario Central | 2:2 | ||||
| 25. Jornada | 11.12.2021 | Rosario Central | - | Huracán | 1:4 |
Argentina
Italia 
