| 1. Jornada | 08.08.2021 | Sporting San Miguelito | - | Alianza | 1:2 | ||||
| 2. Jornada | 16.08.2021 | Plaza Amador | - | Sporting San Miguelito | 0:0 |  |
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| 3. Jornada | 21.08.2021 | Sporting San Miguelito | - | Tauro FC | 1:0 | |
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| 4. Jornada | 30.08.2021 | Sporting San Miguelito | - | Deportivo del Este | 1:1 | |
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| 6. Jornada | 12.09.2021 | Sporting San Miguelito | - | UD Universitario | 1:0 | ||||
| 7. Jornada | 17.09.2021 | Independiente de La Chorrera | - | Sporting San Miguelito | 3:0 | ||||
| 8. Jornada | 26.09.2021 | Veraguas Club Deportivo | - | Sporting San Miguelito | 2:0 | ||||
| 9. Jornada | 03.10.2021 | Sporting San Miguelito | - | Herrera FC | 1:1 |  |
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| 10. Jornada | 10.10.2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 | ||||
| 11. Jornada | 17.10.2021 | Atlético Chiriquí | - | Sporting San Miguelito | 1:1 | ||||
| 12. Jornada | 23.10.2021 | Alianza | - | Sporting San Miguelito | 1:0 | |
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| 13. Jornada | 31.10.2021 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 14. Jornada | 07.11.2021 | Tauro FC | - | Sporting San Miguelito | 1:0 |
Panamá