| 1. Jornada | 07.08.2021 | Guingamp (CFA) | - | FC Rouen 1899 | 0:0 | ||||
| 2. Jornada | 14.08.2021 | AS Vitré | - | Guingamp (CFA) | 0:4 | ||||
| 3. Jornada | 21.08.2021 | Guingamp (CFA) | - | FC Versailles | 0:3 | ||||
| 4. Jornada | 28.08.2021 | US Saint-Malo | - | Guingamp (CFA) | 0:2 | ||||
| 5. Jornada | 04.09.2021 | Guingamp (CFA) | - | Stade Plabennec | 2:1 |  |
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| 6. Jornada | 11.09.2021 | St-Pryvé St-Hilaire | - | Guingamp (CFA) | 1:1 | ||||
| 7. Jornada | 18.09.2021 | Guingamp (CFA) | - | Blois Foot 41 | 2:3 | ||||
| 8. Jornada | 25.09.2021 | Lorient (CFA) | - | Guingamp (CFA) | 3:0 | ||||
| 9. Jornada | 09.10.2021 | Guingamp (CFA) | - | Caen (CFA) | 1:1 | |
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| 10. Jornada | 23.10.2021 | Guingamp (CFA) | - | AS Poissy | 1:1 | ||||
| 14. Jornada | 11.12.2021 | Guingamp (CFA) | - | US Granvillaise | 1:0 | |
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| 16. Jornada | 22.01.2022 | Guingamp (CFA) | - | AS Vitré | 0:5 | ||||
| 13. Jornada | 26.01.2022 | Vannes OC | - | Guingamp (CFA) | 2:0 |
Francia
Costa de Marfil