| 1. Jornada | 17.07.2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 | ||||
| 2. Jornada | 27.07.2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 3. Jornada | 30.07.2021 | Newell's Old Boys | - | Estudiantes | 4:2 | ||||
| 4. Jornada | 02.08.2021 | Patronato de Paraná | - | Newell's Old Boys | 0:0 | ||||
| 5. Jornada | 07.08.2021 | Newell's Old Boys | - | Platense | 1:0 | ||||
| 6. Jornada | 16.08.2021 | Racing Club | - | Newell's Old Boys | 2:0 |  |
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| 7. Jornada | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | ||||
| 8. Jornada | 25.08.2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
| 9. Jornada | 30.08.2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Jornada | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 |  |
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| 11. Jornada | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Jornada | 20.09.2021 | CA Lanús | - | Newell's Old Boys | 1:2 | ||||
| 18. Jornada | 25.10.2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 | |
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| 22. Jornada | 24.11.2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 |
Argentina