| 1. Jornada | 16.07.2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Jornada | 23.07.2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Jornada | 27.07.2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 7. Jornada | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Jornada | 24.08.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 10. Jornada | 03.09.2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 13. Jornada | 24.09.2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 17. Jornada | 18.10.2021 | Platense II | - | Rosario Central II | 0:3 | ||||
| 18. Jornada | 24.10.2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 24. Jornada | 03.12.2021 | Lanús II | - | Rosario Central II | 2:3 |
Argentina