| 1. Jornada | 07.08.2021 | Andrézieux-Bouthéon FC | - | Angers II | 3:1 |  |
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| 2. Jornada | 14.08.2021 | Angers II | - | US Colomiers | 0:0 | ||||
| 4. Jornada | 28.08.2021 | Angers II | - | Canet Roussillon | 2:0 | ||||
| 5. Jornada | 03.09.2021 | Angoulême CFC | - | Angers II | 4:0 |  |
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| 6. Jornada | 11.09.2021 | Angers II | - | Trélissac FC | 0:1 | |
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| 7. Jornada | 18.09.2021 | Moulins Yzeure Foot | - | Angers II | 0:0 | ||||
| 8. Jornada | 25.09.2021 | Angers II | - | AS Béziers | 2:0 | |
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| 3. Jornada | 02.10.2021 | Nantes (CFA) | - | Angers II | 1:1 | |
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| 9. Jornada | 09.10.2021 | Stade Montois | - | Angers II | 0:4 | |
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| 10. Jornada | 23.10.2021 | Angers II | - | Bourges Foot 18 | 0:3 | ||||
| 11. Jornada | 06.11.2021 | Le Puy Foot 43 | - | Angers II | 1:0 | |
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| 13. Jornada | 04.12.2021 | Angers II | - | Vendée Les Herbiers | 2:2 | |
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| 14. Jornada | 11.12.2021 | Montpellier (CFA) | - | Angers II | 0:4 | |
Francia
Camerún