| 1. Jornada | 11.02.2022 | Arsenal de Sarandí | - | Rosario Central | 1:1 | ||||
| 2. Jornada | 15.02.2022 | Rosario Central | - | Vélez Sarsfield | 1:0 |  |
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| 3. Jornada | 20.02.2022 | Boca Juniors | - | Rosario Central | 2:1 | ||||
| 4. Jornada | 26.02.2022 | Rosario Central | - | Godoy Cruz | 1:2 | ||||
| 5. Jornada | 04.03.2022 | Central Córdoba SdE | - | Rosario Central | 0:1 | ||||
| 6. Jornada | 12.03.2022 | Rosario Central | - | Barracas Central | 1:3 | ||||
| 7. Jornada | 20.03.2022 | Rosario Central | - | Newell's Old Boys | 0:1 | ||||
| 8. Jornada | 04.04.2022 | Tigre | - | Rosario Central | 2:0 | ||||
| 9. Jornada | 09.04.2022 | Rosario Central | - | Colón de Santa Fe | 2:2 | ||||
| 10. Jornada | 16.04.2022 | Aldosivi | - | Rosario Central | 1:0 | ||||
| 14. Jornada | 08.05.2022 | Rosario Central | - | Estudiantes | 3:1 |
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