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| 11.03.2022 | 23:15 | Arsenal de Sarandí | - | Vélez Sarsfield | 0:0 (0:0) | |
| 12.03.2022 | 01:30 | Platense | - | Patronato de Paraná | 1:2 (0:1) | |
| 21:00 | Aldosivi | - | Tigre | 1:0 (0:0) | ||
| 21:00 | Huracán | - | Godoy Cruz | 1:3 (1:1) | ||
| 23:15 | Sarmiento de Junín | - | Newell's Old Boys | 2:2 (0:1) | ||
| 23:15 | Rosario Central | - | Barracas Central | 1:3 (1:0) | ||
| 13.03.2022 | 01:30 | Talleres de Córdoba | - | San Lorenzo | 0:1 (0:1) | |
| 21:00 | Unión de Santa Fe | - | Banfield | 2:1 (1:0) | ||
| 21:00 | CA Lanús | - | Colón de Santa Fe | 1:1 (1:0) | ||
| 23:15 | River Plate | - | Gimnasia de La Plata | 4:0 (2:0) | ||
| 14.03.2022 | 01:30 | Estudiantes | - | Boca Juniors | 0:1 (0:0) | |
| 23:15 | Atlético Tucumán | - | Racing Club | 0:4 (0:1) | ||
| 15.03.2022 | 01:30 | Argentinos Juniors | - | Defensa y Justicia | 0:1 (0:0) | |
| 01:30 | Independiente | - | Central Córdoba SdE | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
River Plate | 6 | 4 | 1 | 1 | 13:4 | 9 | 13 |
| 2 |
|
Defensa y Justicia | 6 | 4 | 1 | 1 | 13:10 | 3 | 13 |
| 3 |
|
Unión de Santa Fe | 6 | 4 | 1 | 1 | 6:3 | 3 | 13 |
| 4 |
|
Racing Club | 6 | 3 | 3 | 0 | 12:4 | 8 | 12 |
| 5 |
|
Sarmiento de Junín | 6 | 3 | 2 | 1 | 8:7 | 1 | 11 |
| 6 |
|
Newell's Old Boys | 6 | 3 | 1 | 2 | 9:8 | 1 | 10 |
| 7 |
|
Banfield | 6 | 2 | 2 | 2 | 10:7 | 3 | 8 |
| 8 |
|
Argentinos Juniors | 6 | 2 | 2 | 2 | 7:7 | 0 | 8 |
| 9 |
|
Platense | 6 | 2 | 1 | 3 | 6:6 | 0 | 7 |
| 10 |
|
San Lorenzo | 6 | 1 | 2 | 3 | 5:7 | -2 | 5 |
| 11 |
|
Gimnasia de La Plata | 6 | 1 | 2 | 3 | 5:13 | -8 | 5 |
| 12 |
|
Patronato de Paraná | 6 | 1 | 1 | 4 | 3:8 | -5 | 4 |
| 13 |
|
Atlético Tucumán | 6 | 1 | 1 | 4 | 3:12 | -9 | 4 |
| 14 |
|
Talleres de Córdoba | 6 | 0 | 2 | 4 | 1:5 | -4 | 2 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 6 | 4 | 1 | 1 | 11:8 | 3 | 13 |
| 2 |
|
Colón de Santa Fe | 6 | 3 | 2 | 1 | 9:5 | 4 | 11 |
| 3 |
|
Boca Juniors | 6 | 3 | 2 | 1 | 8:6 | 2 | 11 |
| 4 |
|
Tigre | 6 | 2 | 3 | 1 | 5:3 | 2 | 9 |
| 5 |
|
Huracán | 6 | 3 | 0 | 3 | 8:8 | 0 | 9 |
| 6 |
|
Godoy Cruz | 6 | 2 | 2 | 2 | 10:11 | -1 | 8 |
| 7 |
|
Independiente | 6 | 1 | 4 | 1 | 8:8 | 0 | 7 |
| 8 |
|
Aldosivi | 6 | 2 | 1 | 3 | 5:6 | -1 | 7 |
| 9 |
|
Rosario Central | 6 | 2 | 1 | 3 | 6:8 | -2 | 7 |
| 10 |
|
CA Lanús | 6 | 1 | 3 | 2 | 6:6 | 0 | 6 |
| 11 |
|
Arsenal de Sarandí | 6 | 1 | 3 | 2 | 7:8 | -1 | 6 |
| 12 |
|
Central Córdoba SdE | 6 | 1 | 3 | 2 | 5:6 | -1 | 6 |
| 13 |
|
Vélez Sarsfield | 6 | 1 | 3 | 2 | 3:4 | -1 | 6 |
| 14 |
|
Barracas Central | 6 | 2 | 0 | 4 | 7:11 | -4 | 6 |
| Playoff | |
| Playoff |
