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| 01.04.2022 | 02:30 | Colón de Santa Fe | - | Aldosivi | 1:3 (1:1) | |
| 21:30 | Gimnasia de La Plata | - | Talleres de Córdoba | 2:1 (0:1) | ||
| 02.04.2022 | 00:00 | Patronato de Paraná | - | Unión de Santa Fe | 2:1 (1:0) | |
| 00:00 | Central Córdoba SdE | - | Huracán | 2:2 (2:1) | ||
| 02:30 | Banfield | - | Argentinos Juniors | 0:2 (0:2) | ||
| 02:30 | Barracas Central | - | Independiente | 0:1 (0:0) | ||
| 19:00 | Racing Club | - | Sarmiento de Junín | 4:1 (0:1) | ||
| 21:30 | Vélez Sarsfield | - | CA Lanús | 3:1 (1:1) | ||
| 21:30 | Godoy Cruz | - | Estudiantes | 3:3 (1:0) | ||
| 03.04.2022 | 00:00 | Defensa y Justicia | - | River Plate | 1:2 (0:1) | |
| 02:30 | Boca Juniors | - | Arsenal de Sarandí | 2:2 (1:0) | ||
| 21:30 | San Lorenzo | - | Atlético Tucumán | 1:1 (0:0) | ||
| 04.04.2022 | 00:00 | Newell's Old Boys | - | Platense | 3:1 (1:1) | |
| 02:30 | Tigre | - | Rosario Central | 2:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Club | 8 | 5 | 3 | 0 | 18:6 | 12 | 18 |
| 2 |
|
River Plate | 8 | 5 | 1 | 2 | 15:6 | 9 | 16 |
| 3 |
|
Newell's Old Boys | 8 | 5 | 1 | 2 | 13:9 | 4 | 16 |
| 4 |
|
Argentinos Juniors | 8 | 4 | 2 | 2 | 10:7 | 3 | 14 |
| 5 |
|
Defensa y Justicia | 8 | 4 | 2 | 2 | 15:13 | 2 | 14 |
| 6 |
|
Unión de Santa Fe | 8 | 4 | 2 | 2 | 7:5 | 2 | 14 |
| 7 |
|
Banfield | 8 | 3 | 2 | 3 | 11:9 | 2 | 11 |
| 8 |
|
Sarmiento de Junín | 8 | 3 | 2 | 3 | 10:13 | -3 | 11 |
| 9 |
|
Gimnasia de La Plata | 8 | 2 | 3 | 3 | 8:15 | -7 | 9 |
| 10 |
|
San Lorenzo | 8 | 1 | 4 | 3 | 6:8 | -2 | 7 |
| 11 |
|
Platense | 8 | 2 | 1 | 5 | 7:13 | -6 | 7 |
| 12 |
|
Patronato de Paraná | 8 | 2 | 1 | 5 | 6:12 | -6 | 7 |
| 13 |
|
Talleres de Córdoba | 8 | 1 | 2 | 5 | 4:8 | -4 | 5 |
| 14 |
|
Atlético Tucumán | 8 | 1 | 2 | 5 | 4:14 | -10 | 5 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tigre | 8 | 4 | 3 | 1 | 11:3 | 8 | 15 |
| 2 |
|
Estudiantes | 8 | 4 | 3 | 1 | 15:12 | 3 | 15 |
| 3 |
|
Boca Juniors | 8 | 4 | 3 | 1 | 11:8 | 3 | 15 |
| 4 |
|
Aldosivi | 8 | 4 | 1 | 3 | 11:8 | 3 | 13 |
| 5 |
|
Colón de Santa Fe | 8 | 3 | 3 | 2 | 10:8 | 2 | 12 |
| 6 |
|
Huracán | 8 | 3 | 2 | 3 | 10:10 | 0 | 11 |
| 7 |
|
Independiente | 8 | 2 | 4 | 2 | 10:10 | 0 | 10 |
| 8 |
|
Central Córdoba SdE | 8 | 2 | 4 | 2 | 8:8 | 0 | 10 |
| 9 |
|
Vélez Sarsfield | 8 | 2 | 3 | 3 | 6:6 | 0 | 9 |
| 10 |
|
Godoy Cruz | 8 | 2 | 3 | 3 | 14:16 | -2 | 9 |
| 11 |
|
Barracas Central | 8 | 3 | 0 | 5 | 9:13 | -4 | 9 |
| 12 |
|
Arsenal de Sarandí | 8 | 1 | 5 | 2 | 10:11 | -1 | 8 |
| 13 |
|
Rosario Central | 8 | 2 | 1 | 5 | 6:11 | -5 | 7 |
| 14 |
|
CA Lanús | 8 | 1 | 3 | 4 | 7:10 | -3 | 6 |
| Playoff | |
| Playoff |
