| 4. Jornada | 28.02.2022 | Tacuary | - | Libertad | 0:1 | ||||
| 5. Jornada | 06.03.2022 | Libertad | - | Sportivo Ameliano | 2:0 |  |
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| 6. Jornada | 15.03.2022 | Club Nacional | - | Libertad | 0:3 | ||||
| 7. Jornada | 20.03.2022 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Jornada | 03.04.2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 9. Jornada | 11.04.2022 | Libertad | - | Sol de América | 3:1 | ||||
| 10. Jornada | 18.04.2022 | Cerro Porteño | - | Libertad | 4:0 | |
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| 12. Jornada | 23.04.2022 | Libertad | - | 12 de Octubre de Itauguá | 4:0 | ||||
| 13. Jornada | 30.04.2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 14. Jornada | 08.05.2022 | Libertad | - | Club Olimpia | 1:0 | ||||
| 15. Jornada | 11.05.2022 | Libertad | - | Tacuary | 3:0 | ||||
| 16. Jornada | 15.05.2022 | Sportivo Ameliano | - | Libertad | 1:3 | ||||
| 17. Jornada | 23.05.2022 | Libertad | - | Club Nacional | 1:0 | ||||
| 18. Jornada | 14.06.2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Jornada | 18.06.2022 | Libertad | - | Guaireña FC | 2:0 | ||||
| 20. Jornada | 22.06.2022 | Sol de América | - | Libertad | 0:3 | ||||
| 21. Jornada | 26.06.2022 | Libertad | - | Cerro Porteño | 1:0 |
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