| 7. Jornada | 19.02.2022 | Club Tijuana [Sub 16] | - | CF Monterrey [Sub 16] | 1:0 | ||||
| 8. Jornada | 26.02.2022 | CF Monterrey [Sub 16] | - | Atlético San Luis [Sub 16] | 5:1 |  |
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| 10. Jornada | 12.03.2022 | Mazatlán FC [Sub 16] | - | CF Monterrey [Sub 16] | 2:3 | ||||
| 11. Jornada | 19.03.2022 | CF Monterrey [Sub 16] | - | Atlas Guadalajara [Sub 16] | 1:1 | ||||
| 15. Jornada | 30.03.2022 | Deportivo Guadalajara [Sub 16] | - | CF Monterrey [Sub 16] | 5:1 |  |
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| 13. Jornada | 02.04.2022 | CF Monterrey [Sub 16] | - | Santos Laguna [Sub 16] | 2:1 | ||||
| 14. Jornada | 27.04.2022 | CF Monterrey [Sub 16] | - | UANL Tigres [Sub 16] | 2:3 |
México