| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 | ||||
| 4. Jornada | 14.08.2021 | Pumas UNAM [Sub 20] | - | Gallos Blancos [Sub 20] | 1:4 | ||||
| 5. Jornada | 17.08.2021 | Club Necaxa [Sub 20] | - | Pumas UNAM [Sub 20] | 1:1 |  |
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| 8. Jornada | 12.09.2021 | Pumas UNAM [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 10. Jornada | 25.09.2021 | UANL Tigres [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 12. Jornada | 03.10.2021 | CF América [Sub 20] | - | Pumas UNAM [Sub 20] | 0:0 | ||||
| 13. Jornada | 17.10.2021 | Pumas UNAM [Sub 20] | - | FC Juárez [Sub 20] | 3:0 |
Estados Unidos
México 