| 3. Jornada | 23.01.2022 | Santos Laguna [Sub 18] | - | Club Necaxa [Sub 18] | 1:2 | ||||
| 4. Jornada | 06.02.2022 | Atlas Guadalajara [Sub 18] | - | Santos Laguna [Sub 18] | 2:1 | ||||
| 12. Jornada | 03.04.2022 | Santos Laguna [Sub 18] | - | CF Pachuca [Sub 18] | 3:1 | ||||
| 14. Jornada | 16.04.2022 | Santos Laguna [Sub 18] | - | Gallos Blancos [Sub 18] | 3:0 |  |
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| 15. Jornada | 19.04.2022 | Mazatlán FC [Sub 18] | - | Santos Laguna [Sub 18] | 1:2 | ||||
| 16. Jornada | 24.04.2022 | Santos Laguna [Sub 18] | - | Club León [Sub 18] | 2:3 | ||||
| 17. Jornada | 01.05.2022 | Atlético San Luis [Sub 18] | - | Santos Laguna [Sub 18] | 0:1 |
México