| 11. Jornada | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 14. Jornada | 03.10.2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 15. Jornada | 09.10.2021 | Banfield | - | River Plate | 0:1 | ||||
| 16. Jornada | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 18. Jornada | 26.10.2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
| 22. Jornada | 26.11.2021 | River Plate | - | Racing Club | 4:0 |  |
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| 24. Jornada | 06.12.2021 | River Plate | - | Defensa y Justicia | 2:3 |
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