| 1. Jornada | 05.02.2022 | Resistencia SC | - | Tacuary | 1:0 |  |
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| 2. Jornada | 11.02.2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 3. Jornada | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 | |
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| 4. Jornada | 28.02.2022 | Tacuary | - | Libertad | 0:1 | ||||
| 6. Jornada | 11.03.2022 | Sportivo Ameliano | - | Tacuary | 0:2 | ||||
| 7. Jornada | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 8. Jornada | 04.04.2022 | Guaraní | - | Tacuary | 1:2 | ||||
| 9. Jornada | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
| 10. Jornada | 19.04.2022 | Sol de América | - | Tacuary | 1:0 | |
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| 15. Jornada | 11.05.2022 | Libertad | - | Tacuary | 3:0 | ||||
| 16. Jornada | 16.05.2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 18. Jornada | 13.06.2022 | Club Nacional | - | Tacuary | 3:0 | ||||
| 19. Jornada | 20.06.2022 | Tacuary | - | Guaraní | 0:2 | |
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Paraguay