| 2. Jornada | 12.02.2022 | Guaireña FC | - | Club Olimpia | 1:3 |  |
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| 3. Jornada | 21.02.2022 | Club Olimpia | - | Libertad | 2:2 | |
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| 6. Jornada | 13.03.2022 | Cerro Porteño | - | Club Olimpia | 0:2 | ||||
| 7. Jornada | 21.03.2022 | Club Olimpia | - | Sportivo Ameliano | 0:2 | ||||
| 8. Jornada | 02.04.2022 | Resistencia SC | - | Club Olimpia | 2:1 | |
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| 11. Jornada | 20.04.2022 | Club Olimpia | - | Guaraní | 1:0 | ||||
| 13. Jornada | 02.05.2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
| 14. Jornada | 08.05.2022 | Libertad | - | Club Olimpia | 1:0 | |
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| 15. Jornada | 12.05.2022 | Club Olimpia | - | Sol de América | 1:0 | ||||
| 16. Jornada | 16.05.2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 17. Jornada | 22.05.2022 | Club Olimpia | - | Cerro Porteño | 0:4 | |
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| 18. Jornada | 14.06.2022 | Sportivo Ameliano | - | Club Olimpia | 1:4 | ||||
| 19. Jornada | 19.06.2022 | Club Olimpia | - | Resistencia SC | 6:1 | ||||
| 21. Jornada | 26.06.2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 4:1 |
Paraguay