| 5. Jornada | 03.09.2021 | Angoulême CFC | - | Angers II | 4:0 | ||||
| 6. Jornada | 11.09.2021 | Angers II | - | Trélissac FC | 0:1 | ||||
| 7. Jornada | 18.09.2021 | Moulins Yzeure Foot | - | Angers II | 0:0 | ||||
| 10. Jornada | 23.10.2021 | Angers II | - | Bourges Foot 18 | 0:3 | ||||
| 12. Jornada | 20.11.2021 | Bergerac Périgord FC | - | Angers II | 2:1 |  |
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| 13. Jornada | 04.12.2021 | Angers II | - | Vendée Les Herbiers | 2:2 | ||||
| 14. Jornada | 11.12.2021 | Montpellier (CFA) | - | Angers II | 0:4 | ||||
| 17. Jornada | 05.02.2022 | Angers II | - | Nantes (CFA) | 1:0 | ||||
| 18. Jornada | 12.02.2022 | Canet Roussillon | - | Angers II | 2:0 | ||||
| 20. Jornada | 05.03.2022 | Trélissac FC | - | Angers II | 1:1 | ||||
| 21. Jornada | 12.03.2022 | Angers II | - | Moulins Yzeure Foot | 1:1 | ||||
| 22. Jornada | 19.03.2022 | AS Béziers | - | Angers II | 1:1 | ||||
| 23. Jornada | 26.03.2022 | Angers II | - | Stade Montois | 0:0 | ||||
| 24. Jornada | 09.04.2022 | Bourges Foot 18 | - | Angers II | 0:1 |
Francia