| 5. Jornada | 27.08.2022 | Girondins de Burdeos | - | Guingamp | 0:1 | ||||
| 6. Jornada | 30.08.2022 | Guingamp | - | FC Sochaux | 1:2 |  |
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| 8. Jornada | 12.09.2022 | FC Metz | - | Guingamp | 3:6 | ||||
| 9. Jornada | 17.09.2022 | Guingamp | - | Saint-Étienne | 2:1 | ||||
| 10. Jornada | 01.10.2022 | Chamois Niortais | - | Guingamp | 0:0 | ||||
| 7. Jornada | 04.10.2022 | Guingamp | - | Rodez AF | 0:0 | ||||
| 13. Jornada | 22.10.2022 | Guingamp | - | Bastia | 1:1 | ||||
| 17. Jornada | 30.12.2022 | Guingamp | - | US Quevilly-Rouen | 0:2 | ||||
| 18. Jornada | 10.01.2023 | Amiens SC | - | Guingamp | 1:1 | ||||
| 19. Jornada | 13.01.2023 | Guingamp | - | Grenoble Foot 38 | 2:4 | ||||
| 21. Jornada | 31.01.2023 | Guingamp | - | Nîmes Olympique | 1:2 | ||||
| 25. Jornada | 25.02.2023 | Guingamp | - | Caen | 1:2 | ||||
| 30. Jornada | 08.04.2023 | Havre AC | - | Guingamp | 0:0 | ||||
| 31. Jornada | 15.04.2023 | Guingamp | - | Amiens SC | 3:1 | ||||
| 32. Jornada | 22.04.2023 | Pau FC | - | Guingamp | 2:1 | ||||
| 35. Jornada | 13.05.2023 | FC Sochaux | - | Guingamp | 0:1 | ||||
| 36. Jornada | 20.05.2023 | Guingamp | - | FC Metz | 1:1 | ||||
| 37. Jornada | 26.05.2023 | Guingamp | - | Chamois Niortais | 2:0 | ||||
| 38. Jornada | 02.06.2023 | Grenoble Foot 38 | - | Guingamp | 0:2 |
Francia