| 2. Jornada | 14.08.2021 | Victoria Rosport | - | FC Differdange 03 | 0:3 |  |
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| 1. Jornada | 18.08.2021 | Progrès Niedercorn | - | FC Differdange 03 | 3:0 | ||||
| 4. Jornada | 29.08.2021 | UNA Strassen | - | FC Differdange 03 | 0:1 | ||||
| 5. Jornada | 12.09.2021 | FC Differdange 03 | - | Swift Hesperange | 0:0 | ||||
| 7. Jornada | 22.09.2021 | FC Differdange 03 | - | RM Hamm Benfica | 3:0 | |
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| 8. Jornada | 26.09.2021 | FC Wiltz 71 | - | FC Differdange 03 | 2:1 | ||||
| 9. Jornada | 17.10.2021 | FC Differdange 03 | - | F91 Dudelange | 3:2 | ||||
| 10. Jornada | 24.10.2021 | Jeunesse Esch | - | FC Differdange 03 | 0:0 | ||||
| 11. Jornada | 07.11.2021 | FC Differdange 03 | - | US Hostert | 1:4 | ||||
| 12. Jornada | 21.11.2021 | RFCU Luxemburg | - | FC Differdange 03 | 3:1 | ||||
| 15. Jornada | 12.12.2021 | FC Differdange 03 | - | Etzella Ettelbruck | 4:0 | ||||
| 16. Jornada | 06.02.2022 | FC Differdange 03 | - | Victoria Rosport | 4:0 | |
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| 21. Jornada | 13.03.2022 | RM Hamm Benfica | - | FC Differdange 03 | 0:1 | ||||
| 26. Jornada | 24.04.2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | ||||
| 29. Jornada | 15.05.2022 | Etzella Ettelbruck | - | FC Differdange 03 | 0:2 | ||||
| 30. Jornada | 22.05.2022 | FC Differdange 03 | - | Progrès Niedercorn | 2:0 |
Camerún