| 1. Jornada | 23.07.2021 | FK Lviv | - | FK Mariupol | 1:1 | ||||
| 2. Jornada | 01.08.2021 | FK Mariupol | - | Desna Chernigov | 1:2 | ||||
| 3. Jornada | 07.08.2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 | ||||
| 4. Jornada | 16.08.2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | ||||
| 6. Jornada | 28.08.2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Jornada | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | ||||
| 8. Jornada | 18.09.2021 | FK Mariupol | - | Shakhtar Donetsk | 0:5 | ||||
| 11. Jornada | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 13. Jornada | 30.10.2021 | FK Mariupol | - | Dinamo Kiev | 2:3 | ||||
| 14. Jornada | 06.11.2021 | FC Mynai | - | FK Mariupol | 0:2 | ||||
| 15. Jornada | 21.11.2021 | Vorskla Poltava | - | FK Mariupol | 5:1 |  |
|||
| 17. Jornada | 05.12.2021 | Desna Chernigov | - | FK Mariupol | 3:3 | ||||
| 18. Jornada | 10.12.2021 | FK Mariupol | - | SK Dnipro-1 | 0:3 |
Ucrania