| 4. Jornada | 31.07.2021 | Kuban Krasnodar | - | Spartak Moskva 2 | 1:2 | ||||
| 5. Jornada | 08.08.2021 | Alania Vladikavkaz | - | Kuban Krasnodar | 3:2 |  |
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| 6. Jornada | 14.08.2021 | Kuban Krasnodar | - | Tekstilshchik Ivanovo | 1:0 |  |
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| 10. Jornada | 11.09.2021 | Kuban Krasnodar | - | Metallurg Lipetsk | 0:3 | ||||
| 11. Jornada | 15.09.2021 | Baltika Kaliningrad | - | Kuban Krasnodar | 0:0 |  |
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| 13. Jornada | 25.09.2021 | FK Tom Tomsk | - | Kuban Krasnodar | 2:1 | ||||
| 14. Jornada | 29.09.2021 | Kuban Krasnodar | - | FK Orenburg | 0:1 | |
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| 15. Jornada | 03.10.2021 | Akron Tolyatti | - | Kuban Krasnodar | 1:0 | |
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| 17. Jornada | 13.10.2021 | Rotor Volgograd | - | Kuban Krasnodar | 1:3 | ||||
| 18. Jornada | 17.10.2021 | Kuban Krasnodar | - | FK Kamaz | 1:0 | ||||
| 19. Jornada | 23.10.2021 | FK Krasnodar 2 | - | Kuban Krasnodar | 1:2 | ||||
| 20. Jornada | 31.10.2021 | Kuban Krasnodar | - | Enisey Krasnoyarsk | 2:1 | |
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| 21. Jornada | 06.11.2021 | Veles Moskva | - | Kuban Krasnodar | 1:0 | ||||
| 23. Jornada | 17.11.2021 | Kuban Krasnodar | - | Alania Vladikavkaz | 5:5 | ||||
| 25. Jornada | 27.11.2021 | Kuban Krasnodar | - | Olimp-Dolgoprudny | 0:2 | |
Rusia