| 1. Jornada | 24.07.2011 | CF Pachuca | - | Santos Laguna | 1:4 |  |
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| 2. Jornada | 31.07.2011 | Santos Laguna | - | Atlante | 3:0 | ||||
| 4. Jornada | 07.08.2011 | Santos Laguna | - | Club Tijuana | 1:3 |  |
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| 5. Jornada | 14.08.2011 | Pumas UNAM | - | Santos Laguna | 1:1 | |
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| 7. Jornada | 28.08.2011 | CF Monterrey | - | Santos Laguna | 2:0 | ||||
| 8. Jornada | 11.09.2011 | Santos Laguna | - | Deportivo Guadalajara | 1:1 | |
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| 9. Jornada | 18.09.2011 | Club San Luis | - | Santos Laguna | 0:1 | ||||
| 10. Jornada | 25.09.2011 | Puebla FC | - | Santos Laguna | 1:2 | |
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| 11. Jornada | 02.10.2011 | Santos Laguna | - | Cruz Azul | 1:0 | |
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| 12. Jornada | 09.10.2011 | Gallos Blancos (old) | - | Santos Laguna | 1:3 | |
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| 13. Jornada | 16.10.2011 | Santos Laguna | - | Deportivo Toluca | 3:2 | |
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| 6. Jornada | 02.11.2011 | Santos Laguna | - | Monarcas Morelia | 0:2 | ||||
| 17. Jornada | 06.11.2011 | Santos Laguna | - | Atlas Guadalajara | 3:0 | |
México
