| 1. Jornada | 26.07.2021 | Cruz Azul [Sub 20] | - | Mazatlán FC [Sub 20] | 1:1 | ||||
| 2. Jornada | 30.07.2021 | Mazatlán FC [Sub 20] | - | CF Pachuca [Sub 20] | 1:1 | ||||
| 3. Jornada | 06.08.2021 | Mazatlán FC [Sub 20] | - | CF Monterrey [Sub 20] | 1:4 | ||||
| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 13. Jornada | 15.10.2021 | Mazatlán FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 | ||||
| 14. Jornada | 19.10.2021 | Puebla FC [Sub 20] | - | Mazatlán FC [Sub 20] | 2:1 | ||||
| 15. Jornada | 22.10.2021 | Mazatlán FC [Sub 20] | - | Gallos Blancos [Sub 20] | 4:0 | ||||
| 16. Jornada | 29.10.2021 | Club Necaxa [Sub 20] | - | Mazatlán FC [Sub 20] | 1:1 | ||||
| 17. Jornada | 05.11.2021 | Mazatlán FC [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:0 |  |
México