| 1. Jornada | 16.07.2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Jornada | 23.07.2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Jornada | 27.07.2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 |  |
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| 4. Jornada | 30.07.2021 | Rosario Central II | - | Aldosivi II | 4:1 | |
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| 7. Jornada | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Jornada | 24.08.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 9. Jornada | 30.08.2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 14. Jornada | 01.10.2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 20. Jornada | 05.11.2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 |
Paraguay