| 1. Jornada | 07.08.2021 | Lyon (CFA) | - | Mónaco (CFA) | 1:0 | ||||
| 2. Jornada | 14.08.2021 | FC Martigues | - | Lyon (CFA) | 1:1 | ||||
| 3. Jornada | 21.08.2021 | Lyon (CFA) | - | GFA Rumilly Vallières | 0:2 | ||||
| 4. Jornada | 28.08.2021 | AS Saint-Priest | - | Lyon (CFA) | 1:3 | ||||
| 10. Jornada | 23.10.2021 | Marignane Gignac FC | - | Lyon (CFA) | 4:0 | ||||
| 11. Jornada | 06.11.2021 | Lyon (CFA) | - | SC Toulon | 0:0 | ||||
| 12. Jornada | 20.11.2021 | Lyon (CFA) | - | RC Grasse | 1:0 | ||||
| 14. Jornada | 11.12.2021 | Lyon (CFA) | - | Hyères FC | 3:2 | ||||
| 13. Jornada | 18.12.2021 | Louhans-Cuiseaux | - | Lyon (CFA) | 1:2 | ||||
| 16. Jornada | 22.01.2022 | Lyon (CFA) | - | FC Martigues | 0:1 | ||||
| 23. Jornada | 26.03.2022 | Marsella (CFA) | - | Lyon (CFA) | 0:2 |  |
Francia