| 1. Jornada | 16.07.2021 | Godoy Cruz II | - | Rosario Central II | 1:1 | ||||
| 2. Jornada | 23.07.2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Jornada | 27.07.2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 4. Jornada | 30.07.2021 | Rosario Central II | - | Aldosivi II | 4:1 | ||||
| 5. Jornada | 06.08.2021 | Sarmiento de Junín II | - | Rosario Central II | 2:2 | ||||
| 8. Jornada | 24.08.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 | ||||
| 13. Jornada | 24.09.2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Jornada | 01.10.2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Jornada | 08.10.2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 19. Jornada | 29.10.2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 | ||||
| 20. Jornada | 05.11.2021 | Defensa y Justicia II | - | Rosario Central II | 1:2 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central II | - | River Plate II | 2:0 | ||||
| 24. Jornada | 03.12.2021 | Lanús II | - | Rosario Central II | 2:3 |
Argentina