| 8. Jornada | 26.02.2022 | CF Pachuca [] | - | FC Juárez [] | 4:0 |  |
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| 9. Jornada | 05.03.2022 | Deportivo Toluca [] | - | CF Pachuca [] | 2:4 | ||||
| 11. Jornada | 19.03.2022 | Puebla FC [] | - | CF Pachuca [] | 0:3 | |
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| 12. Jornada | 26.03.2022 | CF Pachuca [] | - | Pumas UNAM [] | 2:2 | |
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| 13. Jornada | 03.04.2022 | FC Juárez [] | - | CF Pachuca [] | 1:4 | |
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| 14. Jornada | 09.04.2022 | CF Pachuca [] | - | Club Necaxa [] | 0:1 | ||||
| 16. Jornada | 24.04.2022 | CF América [] | - | CF Pachuca [] | 4:3 | |
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| 17. Jornada | 30.04.2022 | CF Pachuca [] | - | Deportivo Toluca [] | 0:2 | ||||
| 18. Jornada | 07.05.2022 | Gallos Blancos [] | - | CF Pachuca [] | 0:0 |
México